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Yonghong Liang Ph.D. I-Curriculum Vitae

Yonghong Liang Ph.D. I-Curriculum Vitae

Izimpumelelo ezinkulu

Uhlolo Lokucwaninga

  • Sep. 2006-okwamanje Ukusebenza ku-Ph.D (i-Organic Chemistry)
    Projects
    I-1. Ucwaningo oluthile lokuxhumana phakathi kwe-dapivirine (TMC120) ne-HIV-1 reverse transcriptase
    I-2. Ubuhlobo obuningi bokuhlelwa kwesenzo-umsebenzi wokufunda i-benzyl ebizwa ngokuthi i-diarylpyrimidines
    I-3. Ukuklama, ukuhlanganiswa kanye nezifundo ze-SAR ze-α noma β naphthyl i-diarylpyrimidines njenge-non-nucleoside inhibitors ye-HIV-1 reverse transcriptase
    I-4. Ukuklama nokuhlanganiswa kwama-DABO njengama-inhibitors womabili we-HIV-1 reverse transcriptase ne-integrase

  • 2003-2006 I-Master Candidate
    Projects
    I-1. Ukudluliswa kwe-proton-intro-intramolecular proton ye-2-hydroxybenzophenone, i-8-hydroxy-4H-naphthalen-1-one, i-5-hydroxy-4, i-5-naphthoquinone, i- 1-hydroxy-9, i-10-anthraquione, i-7-i-Hydroxy -1-indenone, 5, 8-dihydroxy-1, 4-naphthoquinone), 4, 9-dihydroxyperylene-3, i-10-quinone ne-hypocrellin A yafundwa ngezindlela zemfundiso.
    I-2. I-state-state ukudluliswa kwe-proton ye-inermolecular kulezi zinkimbinkimbi ze-5-hydroxyisoxazole-amanzi, i-DNA (RNA) base dimer kanye ne-base-N-methylformamide yenziwa ngezindlela ze-DFT.
    Uhlobo lwe-2002-2003 Ubuhlobo bomhlaba obunamakhemikhali kumhlaba we-physicochemical we-ketone ne-aldéhyde

Imiklomelo

Isifundazwe saseHunan ubuciko beNkosi Master, 2008

Publications

I-1. I-Liang, YH; Chen, FE ONIOM DFT / PM3 ukubalwa kokuxhumana phakathi kwe-interndapivirine kanye ne-HIV-1 reverse transcriptase, isifundo somqondo. I-Drug Discov. Ther. 2007, 1, 57-60.

I-2. I-Liang, YH; Ucwaningo lwe-FE, i-FE QSAR ye-diarylpyrimidines ngokumelene ne-HIV-1 reverse transcriptase nezinhlobo ze-wild and type mutant. I-Eur. J. Med. I-Chem. 2009, 44, 625-631

I-3. I-Liang, YH; I-Feng, i-XQ; I-Zeng, i-ZS; Chen, FE; I-Balzarini, J .; I-Pannecouque, i-C .; De Clercq, E. Design, Synthesis, ne-SAR ye-Naphthyl-Substituted Diarylpyrimidines njenge-Non-Nucleoside Inhibitors ye-HIV-1 Reverse Transcriptase. I-ChemMedChem 2009, i-4, i-1537-1545.

I-4. I-Feng, i-XQ; I-Liang, YH; I-Zeng, i-ZS; Chen, FE; I-Balzarini, J .; I-Pannecouque, i-C .; De Clercq, E. Ukulungiswa kwesakhiwo se-DAPY Analogues nomsebenzi onamandla we-Anti-HIV-1. I-ChemMedChem 2009, i-4, i-219.

I-5. I-Zeng, i-ZS; I-Liang, YH; I-Feng, i-XQ; Chen, FE; I-Balzarini, J .; I-Pannecouque, i-C .; De Clercq, E. Ukuqondisa phambili kwe-diarylpyrimidines njenge-inhibitors ye-non-nucleoside i-HIV-1 reverse transcriptase, i-ChemMedChem 2010, eyamukelwe.

I-6. I-Liang, YH; Yi, PG Ucwaningo lwezingqungquthela ngesakhiwo, amandla kanye ne-intramolecular transfer of alkannin. I-Chemical Physics Letters, i-2007, i-438, i-173.

I-7. I-Liang, YH; I-Yi, i-PG; Peng, HL Ucwaningo lwama-structural design, amandla enamandla kanye ne-intramolecular transfer of hypocrellin A. I-Chemical Physics Lettters, i-2008, i-466, i-6-10.

I-8. I-Liang, YH; I-Yi, i-PG. I-Cao, i-CZ Ucwaningo lwezincazelo mayelana nokuthunyelwa kwe-proton okusizwa nge-Solvent ku-5-hydroxyisoxazole. I-Journal ye-Molecular Structure: Theochem, 2005, 729, 163-167.

I-9. I-Yi, i-PG .; I-Liang, YH; I-Cao, i-CZ I-proton ye-Intramolecular noma i-hydrogen-atom ukudluliselwa emazweni aphansi futhi ajabule ka-2-hydroxybenzophenone: Isifundo se-theory. I-Physics ye-Chemical, i-2005, i-319, i-297.

I-10. I-Yi, i-PG .; U-Liang, YH Ucwaningo lwama-conjugation kanye nemiphumela ensizayo ekudluliseni kwe-prothamolecular proton emazweni aphansi kanye nesithakazelo. I-Physics ye-Chemical, i-2006, i-322, i-382.

I-11. I-Yi, i-PG .; ULiang, YH Tang, ZQ Ucwaningo lwezintambo zokuphendula kwe-proton ye-intermoleculars ezindaweni ezihlukanisiwe ze-5-hydroxyisoxazole-water complexes. I-Physics ye-Chemical, i-2006, i-2006, i-322, i-387.

I-12. I-Liang, YH; I-Zeng, i-ZS; I-Feng, i-XQ; Chen, FE; I-Balzarini, J .; I-Pannecouque, i-C .; De Clercq, E. Parallel Synthesis and Biological Evaluation of Diarylpyrimidines nge Potent Anti-HIV-1 Umsebenzi. I-Med. I-Chem. 2010, 18 (13), i-4601.

I-13. I-Liang, YH; I-Zeng, i-ZS; I-Feng, i-XQ; Chen, FE; I-Balzarini, J .; I-Pannecouque, i-C .; De Clercq, E. Ukuklama kwama-DABO njengama-inhibitors womabili we-HIV-1 reverse transcriptase ne-integrase. J. Med. I-Chem.

I-14. Chen, FE, Liang, YH Inqubekela-phambili Yamuva ku-Multi-target Anti-AIDS Izidakamizwa, Ukuthuthuka Kwezokwelapha (8), Peng, SQ Ed., 2011, 167.

I-15. Chen, FE, Liang, YH, Zeng, ZS PCT / CN2009 / 075931.

I-16. Zeng, ZS, Liang, YH, Zhang, JY, Xiong, JC China Patent, i-CN201110070027.4

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