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I-2019 CNS Ukwelapha I-Sodium Monosialotetrahexosylganglioside (GM1) I-Pig Brain (37758-47-7)

I-2019 CNS Ukwelapha I-Sodium Monosialotetrahexosylganglioside (GM1) I-Pig Brain (37758-47-7)

Incazelo ye-Meta

Thola indima ye-GM1 ebuchosheni be-neurological, izakhiwo zayo eziguga ukuguga, kanye nemiphumela yomtholampilo ohlelweni lwezinzwa eziphakathi nendawo.

Iyini i-Monosialotrahexosylganglioside Solidum (GM1)

I-sodium ye-Monosialotetrahexosylganglioside isisindo se-neurotrophic esichazayo GM1.

Ama-gangliosides ayingxenye yezinhlayiya ze-ganglio, eziqukethe i-glycosphingolipid ene-sialic acid yokuhlala e-chain chain. Ikhebula le-polysaccharide le-sialated lixhuma nge-ceramide ngexhumano lwe-β-glycosidic. Abagcini nje kuphela ngaphakathi kwendwangu ye-plasmic ye-neuronal kodwa futhi nase-endoplasmic reticulum.

Nakuba zihlanganisa i-0.1% yesisindo esiphezulu sobuchopho, i-gangliosides akhawunti cishe ye-10% ye-lipids jikelele. Zenza ukuhlukaniswa kweseli, i-apoptosis, i-neuroprotection, nokukhululwa kwe-neurotrophins.

I-Monosialotetrahexosylganglioside iyinhlanganisela engavumelani ehlanganisa i chain oligosaccharide ne-ceramide. I-molecule iyabonisa kokubili i-hydrophilic ne-lipophilic properties. Njengoba i-soluble emanzini namafutha, i-Monosialotetrahexosylganglioside ingakwazi ukuhamba kalula ngokusebenzisa isivinini se-brain-brain.

Sodium ye-Monosialotetrahexosylganglioside GM1 idlala indima ebalulekile yomzimba ebuchosheni. Ikhombisa izinto eziphathelene neuroprotective ezifana nokulungisa umonakalo wegazi, ukuvuselela ukusebenza, nokuvuselelwa kwe-neurons ngemuva kokulimala. Ngenxa yalesi sizathu, i-sodium ye-Monosialotetrahexosylganglioside iyasiza ekwelapheni ukulimala okuphakathi komzwelo. Ezinye zezifo ezihlobene nazo zihlanganisa ukuhlukunyezwa kwe-cerebrospinal, ukulimala kwe-cerebrovascular, kanye nokulimala kwesisindo se-nerumatic cell. Okunye okugxilwe kukho lapho kunomonakalo we-cell nerve.

Umlando we-Sodium Monosialotetrahexosylganglioside (GM1)

Ukutadisha kwe-GM1 nendima yayo i-neuroprotection ibuyela emuva kuma-1970. Kusukela ngaleso sikhathi, ososayensi ocwaningayo baye babonisa isithakazelo kulolu hlobo ngokuqhuba amasiko esilwane nezifundo zezilwane. Zonke izivivinyo zigxile ekusunguleni ukubaluleka kwe-GM1 ezinkingeni ezingenayo i-neurodegenerative.

Ku-1986, nge-TRB SA, sodium ye-Monosialotetrahexosylganglioside yaqala ngokusemthethweni ngaphansi kwegama lebhizinisi, GM-1. Njengoba kunikezwe ukuthi imiphumela yezifundo zesilwane yayithembisa, odokotela base-US bahamba ukuyohlola imiphumela ye-Monosialotetrahexosylganglioside sodium (GM1) kubantu. Izifundo zalolu cwaningo zaziyiziguli ezinomonakalo we-CNS ngenxa yokulimala kwentambo yomgogodla, isifo, isifo sikaParkinson, i-Alzheimer.

Kusukela ngaleso sikhathi, kuthiwa i-Argentina ne-Italy baye bayamukela uhlelo lwayo lwezokwelapha njengesidakamizwa somuthi wokunakekelwa kwezimo zezinzwa.

Sodium ye-Monosialotetrahexosylganglioside(GM1)I-Structure Formula

Ubuchopho bezinsobe ze-sodium (i-GM1) i-Monosialotetrahexosylganglioside (37758-47-7)

Sodium ye-Monosialotetrahexosylganglioside(GM1) Imininingwane

CAS Cha 37758-47-7
Igama Product I-Sodium ye-Monosialotetrahexosylganglioside (GM1) I-pig Brain
Igama le-IUPAC (2S,4S,5R,6R)-5-acetamido-2-[(2S,3R,4R,5S,6R)-5-[(2S,3R,4R,5R,6R)-3-acetamido-5-hydroxy-6-(hydroxymethyl)-4-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-2-[(2R,3S,4R,5R,6R)-4,5-dihydroxy-6-[(E,2R,3S)-3-hydroxy-2-(icosanoylamino)icos-4-enoxyl]-2-(hydroxymethyl)oxan-3-yl]oxy-3-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid
I-Drug Class Sphingolipids
I-Melting Point 207 - 230 ° C
Formula Yamamolekhula C77H139N3O31
Mass Mass I-1546.841 gmol-1
solubility · Amanzi
· Kancane kancane ku-methanol / chloroform
· Okungapheliyo ethanol anhydrous
ukubukeka I-white to off-white lyophilized powder
Ukuhlanzeka 98%
Isitoreji Temperature -20 ° C
Shelf Life Iminyaka emibili
pH 5.0 ukuze 6.5
omqondofana · I-Monosialoganglioside GM1
·I-Ganglioside GM1

Sodium ye-Monosialotetrahexosylganglioside(GM1) Indlela Yokusebenza

I-monosialotetrahexosyl ganglioside isebenza ngezindlela eziningana. I-molecule iyingxenye enkulu yemisebenzi yemvelo yesimiso sezinzwa.

Esikhathini sekhanda lesikhumba sobuchopho, imisebenzi ye-Monosialotetrahexosylganglioside ukulondoloza ibhalansi ye-ion ngaphakathi nangaphandle kwezingcubu ze-membranous. Akukona nje ukukhulisa ukungapheleli, kodwa futhi kuveza ne-sodium ne-calcium ion pump.

Endabeni yokulimala kwesibindi, Sodium ye-Monosialotetrahexosylganglioside (GM1) iza ukuvikela isakhiwo sekhanda. Ihlisela phansi umsebenzi we-phospholipase A2, ihlaziya i-calcium ion influx, futhi isika phansi ukubunjwa kwama-radicals mahhala.

I-traumas traumas yenza umsebenzi weprotein kinase kumaseli, okungenzeka abe nomthwalo we-apoptosis. I-GM1 inhibitshi futhi iguqula le nqubo ngokubamba imetabolism yamaprotheni ngaphakathi kwe-cytoplasm ne-nucleus.

Ngaphakathi kwe-mitochondrion, i-Monosialotetrahexosylganglioside isebenza ukuhlehlisa ukukhiqizwa kwe-ATP nomsebenzi wayo we-synthase. Lalungisa ukulimala okungenzeka kulayini lokuthutha lwe-electron futhi kuthuthukise i-phosphorylation ye-oxidative. Ngenxa yalokho, umsebenzi wokuphefumula we-mitochondrial uhlala unempilo.

Umjovo we-sodium i-Monosialotetrahexosylganglioside uvuselela ukuhluma kwe-axonal ngokugxila ekukhuleni kwezimo ezithintekayo kwi-receptors. Lo msebenzi uvuselela izintambo zezinzwa futhi ukhuthaze ukuphola ngokushesha kwegazi. Endabeni yokuguqulwa kwesibili, mhlawumbe ngenxa yokulimala kwe-dopamine neuron, i-Monosialotetrahexosylganglioside izoqinisa umphumela futhi ikhulise ukusinda kwala ma-neurons.

I-2019 CNS Ukwelapha I-Sodium Monosialotetrahexosylganglioside (GM1) I-Pig Brain (37758-47-7)

Imiphumela ye-Monosialotrahexosylganglioside Solidum (GM1)

Nakuba i-gangliosides yiyona encane ebuchosheni, imisebenzi yabo inkulu kakhulu. Lezi zinhlayiya zinethonya elihle ekukhuleni, ukuvuselelwa, ukulungiswa nokuvikelwa kwezintambo zomzimba.

I-GM1 inqotshwa ngeminyaka. Ukuguga kuhlotshaniswa nokusetshenziswa ngokweqile kobuchopho, ukukhanya okulula, ukulimala kwamangalisa ngengozi, noma ukulahlekelwa kwememori. Ngaphandle kwalokho, izifo ezindala ezinjenge-cerebral palsy, isifo sohlangothi, nesifo sengqondo se-dementia cishe zizovela.

Ukwengezwa okwesikhashana kwe-GM1 exoxa kusiza ukuphatha iningi le-syndromes yokuguga. Ezinye ze-Monosialotetrahexosylganglioside sodium (GM1) imiphumela ihlanganisa ukwelashwa kwesifo se-Alzheimer, isifo sokushaya isisu, isithuthwane nesifo se-cerebral palsy. Ngaphandle kwalokho, ukwesekwa kunciphise ukuguga ngcono inkumbulo.

Ukusetshenziswa kwe-GM1 kwizicelo zemitholampilo kukhulu kakhulu. Isibonelo, amazwe amaningi aseYurophu naseMelika asethathe umjovo we-sodium monosialotetrahexosylganglioside ukuphatha izifo ze-CNS.

Ukwengeza kukhulisa ukukhula kwamangqamuzana omzimba, ukuthuthukiswa kwezicubu zobuchopho nokuvimbela ukuphazamiseka kwezinzwa. Ngokwelashwa, le molekyuli exogene isebenza ngezifo zobuchopho, ukulimala kwe-ischemic, ukulimala kwe-cerebral, kanye nokulimala kwamangqamuzana e-nerumatic cell.

Ukuphumelela okuphawulekayo ekutadisheni nasekusetshenzisweni kwalesi sakhi kubantu kwakuthola ukuthi akubanga nemiphumela emibi ye-Monosialotetrahexosyl ye-ganglioside (i-GM1) imiphumela.

Imiphumela ye-GM1 ayiyona into ecatshangelwayo. Ku-1976, i-Ceccarelli yasungula ukuthi ama-ganglioside angenangqondo avuselela ukuguqulwa kwamantombazane aphakathi nendawo kanye nokulungiswa kwamaseli awonakele. Lokhu kutholakala kwabeka isisekelo esiqinile sabafundi ababonisa isithakazelo ekutadisheni indima ye-GM1 ohlelweni lwezinzwa eziphakathi.

Izibalo zezilingo zomtholampilo ziqinisekisa ukuthi i-Monosialotetrahexosylganglioside inegalelo elihle ekukhuleni, ekuhlukaniseni, ekuthuthukiseni nasekuvuselelweni kwamangqamuzana egazi. Ngaphezu kwalokho, ucwaningo luvuselela ukusebenza kahle kwe-GM1 ekuvimbeleni i-neuroprotection, i-neuroplasticity, nokudluliselwa kwe-synaptic.

Endabeni yokuhlukumezeka, ukuthatha umjovo we-sodium we-Monosialotetrahexosylganglioside exoxa uzothinta isistimu yezinzwa ngezindlela eziningana. I-molecule ngeke ivuselele kuphela isizukulwane se-dendritic samangqamuzana omzimba kodwa futhi yandisa izinga lokusinda. Okwesibili, ukwesekwa kunendima ebalulekile ekulungiseni, ukuvuselelwa kabusha nokuvuselela ukusebenza.

I-Monosialotrahexosyl i-Ganglioside Solidum (GM1) Indlela yokukhipha

Kuze kube manje, i-Monosialotetrahexosyl ganglioside yilapho kuphela ukwelashwa kwe-CNS okwenzeka ngokwemvelo.

I-molecule iyisakhi se-ganglioside, esakhiwe ngokugcwele emgqonyeni we-neural cell wezilwane ezincelisayo. Ngenxa yokuqukethwe kwayo okucebile kwezicubu zezinzwa, ososayensi nabahlengikazi baye bakwazi ukukhipha futhi bayisebenzise ekulungiseleleni i-ganglion monosialotetrahexose yezokwelapha.

Sithatha i-Monosialotetrahexosyl ganglioside kusuka kumaseli wamamamalia. Nakuba ungakwazi ukuhlukanisa i-molecule yenkomo noma imbuzi, indlela ephephile kakhulu i-pig brain. Isizathu ukuthi ukukhishwa kwe-Monosialotetrahexosyl ye-ganglioside kusuka ezinkabeni noma ezimbuzi cishe kuzodlulisela izimpendulo ezithathelwanayo ezifana nesifo se-cow-cow kanye nesithuthwane.

Izinto zokwakha ze-Monosialotetrahexosylganglioside sodium (GM1) yilezi zelabhu zifinyeleleka, ziphumelele, futhi ziyanconywa. Sinikeza i-GM1 ephephile futhi ehlanzekile kusuka ebuchosheni bezingulube, njengoba indlela engadlulisi izifo kubantu.

Ukuze uthole isivuno esikhulu, sisebenzisa indlela yokuchithwa kwamanzi e-chloroform-methanol. Ngemuva kwalokho, senza ukushintshaniswa kwe-anion nokuhlukaniswa kwe-size-exclusion chromatographic. Lokhu kuhlanzwa kuveza i-molecule ene-homogenous, i-98% ehlanzekile nge-HPLC.

Isiphetho

Imiphumela ye-Monosialotetrahexosyl ye-ganglioside ibalulekile emisebenzini yomtholampilo. Liyisidakamizwa esivunyelwe ukuthi ilawulwe izifo ze-neurological kanye nokwelashwa kokulimala okuphakathi kwemizwa.

Kungakhathaliseki ukuthi ufuna ukuthenga i-GM1 ngezinjongo zokwelapha noma izinhloso zocwaningo, sikuqinisekisa ukuthi umkhiqizo ophezulu. Senza ukukhiqiza ivolumu I-sodium ye-Monosialotetrahexosylganglioside (GM1) ngaphansi kwamazinga okulawulwa kwekhwalithi evumelekile.

Okubhekwayo

  1. Schneider, JS, Roeltgen, DP, et al. (I-1998). Izifo zikaPasinson: Umsebenzi ophuthumayo Ngokwelashwa kwe-GGNNUMX ye-Ganglioside Esifundweni Esilawulwa Ngendawo Engahleliwe.
  2. Bansal, AS, Abdul-Karim, B., Malik, RA, et al. (I-1994). I-IgM Ganglioside I-GM1 Antibodies ezigulini ezinezifo ezizenzakalelayo noma ze-Neuropathy, ne-Controls. I-Journal Clinical Pathology.
  3. Mocchetti, I. (2005). I-Gangliosides engavamile, i-Neuronal Plastic and Repair, ne-Neurotrophins.
  4. Aureli, M., Mauri, L., Ciampa, MG, Prinetti, A., Toffano, G., et al. (I-2016). I-GM1 Ganglioside: Izifundo Ezidlule Nezikhathi Ezizayo. I-Neurobiology yamangqamuzana.
  5. Bian, L., Yang, J., ne-Sun, Y. (2015). Ukuhlukaniswa nokuhlanzwa kwama-Monosialotetrahexosylgangliosides kusuka ku-Pig Brain nge-Extraction kanye ne-Liquid Chromatography.